Deep brain stimulation of the subthalamic nucleus is a clinically effective tool for treating medically refractory Parkinson’s disease, but its neural mechanisms remain debated. Previous work has demonstrated that STN DBS results in evoked potentials in the primary motor cortex, suggesting that modulation of cortical physiology may be involved in its therapeutic effects. Due to technical challenges presented by high-amplitude DBS artifacts, these EPs are often measured in response to low-frequency stimulation, which is generally ineffective at PD symptom management. This (...) study aims to characterize STN-to-cortex EPs seen during clinically relevant high-frequency STN DBS for PD. Intraoperatively, we applied STN DBS to 6 PD patients while recording electrocorticography from an electrode strip over the ipsilateral central sulcus. Using recently published techniques, we removed large stimulation artifacts to enable quantification of STN-to-cortex EPs. Two cortical EPs were observed – one synchronized with DBS onset and persisting during ongoing stimulation, and one immediately following DBS offset, here termed the “start” and the “end” EPs respectively. The start EP is, to our knowledge, the first long-latency cortical EP reported during ongoing high-frequency DBS. The start and end EPs differ in magnitude and latency, and the end, but not the start, EP magnitude has a significant relationship to ongoing high gamma power during the EP. These contrasts may suggest mechanistic or circuit differences in EP production during the two time periods. This represents a potential framework for relating DBS clinical efficacy to the effects of a variety of stimulation parameters on EPs. (shrink)

What are the landmarks of the cognitive revolution? What are the core topics of modern cognitive science? Where is cognitive science heading to? Leading cognitive scientists--Chomsky, Pylyshyn, Gallistel, and others--examine their own work in relation to one of cognitive science's most influential and polemical figures: Jerry Fodor.

Gleitman and Trueswell’s “The easy words” forms a pair with their earlier paper, “Hard words,” completing a circle in which the authors ask how “easy” words (e.g., concrete nouns) are learned. They take up the hypothesis of “cross‐situational learning,” and argue that accumulating observations actually hinders learning if the mechanism requires holding all exemplars in memory over time. They present an alternative hypothesis, “Propose but Verify,” wherein people use one‐trial learning to confirm or disconfirm their current hypothesis—a mechanism distinctly different (...) from cross‐situational learning. (shrink)

The article proposes that the modern notion of the spiritual in art, which was theorized at the beginning of the twentieth century, although remains pivotal to the discourse of art and the spiritual, has radically shifted as a result of changing attitudes to the body–mind relations instigated by popular trends of contemporary spiritualities. This cultural tendency is demonstrated by the analysis of the networked art form of Moon Ribas, e.g., dance with earthquakes. Ribas performs a cyborg body and consciousness that, (...) as contended, could be holistically enhanced and develop a unique compassionate awareness. In addition, I reflect on two examples from my performative practice of Networked Rites that interplay with speculative metaphors, spiritual and shamanic techniques, networked aesthetic forms and technologies. The first invokes communitas as a collective, non-local, networked noetic field. The second utilizes a decision-making app as a mediating device between the body and mind for the making of a prototype cyborg noetic field instilled with auspicious resonance. The article mainly implies that spiritual art continues to evolve through technoetic aesthetics fusing emerging technologies, science and shamanic, spiritual insight. Current trends may develop into benevolent and experiential applications based on the interrelations of human and cyborg body and consciousness. (shrink)

Apart from references to perception, words such asseeandlistenhave shared, non-literal meanings across diverse languages. Such cross-linguistic meanings have not been systematically investigated as they appear in their natural home — informal spoken interaction. We present a qualitative examination of the semantic associations of perception verbs based on recorded everyday conversation in thirteen diverse languages. Across these diverse communities, spontaneous interaction provides evidence for two commonly-discussed extensions of perception verbs — perception~cognition, hearing~linguistic communication — as well as illustrating other meanings and (...) functions (e.g., the use of perception verbs as discourse markers) that have been less appreciated heretofore. The range of usage that is readily observable in informal conversation makes it clear that this type of data must take center stage for the empirically grounded study of semantics. Moreover, these data suggest that commonalities in polysemous meanings may rely not only on universal cognition, but also on the universal exigencies of social interaction. (shrink)

Ritual consciousness is an altered state of consciousness that transpires beyond the boundaries of the known and gives rise to a duration referred to as time out of time. This extraordinary duration encompasses three interrelated factors: digital as opposed to analogue conduct of time, tempo and communitas. Under specific formal conditions, these factors may emerge in the context of networked rituals and outside their traditional and earthbound religious or spiritual settings. In this article, the three factors are analysed in relation (...) to the author’s networked rites on the Waterwheel platform. The rites are designed to explore ritual consciousness and produce prototype morphic fields of compassion, which are aimed at counteracting the prevalent narrative of violence. There is an emphasis on communitas, a liminal and nonhierarchical communal state of oneness that could generate compassion. Based on researches in anthropology, biogenetic structuralism, cognitive neuroscience and morphic resonance, communitas is metaphorically envisioned as the communion of non-local brains within a networked mind and morphic field. The article postulates that the virtual and organic hybridity of the rites involve the participants’ body, brain and fields of the mind in the explorations of ritual consciousness. (shrink)

ABSTRACT:Neuroethics, the study of the cognitive and neural mechanisms underlying ethical decision-making, is a growing field of study. In this review, we identify and discuss four themes emerging from neuroethics research. First, ethical decision-making appears to be distinct from other types of decision-making processes. Second, ethical decision-making entails more than just conscious reasoning. Third, emotion plays a critical role in ethical decision-making, at least under certain circumstances. Lastly, normative approaches to morality have distinct, underlying neural mechanisms. On the basis of (...) these themes, we draw implications for research in business ethics and the practice of ethics training. (shrink)

Currently, brain tissue transplantations are being developed as a clinical-therapeutic tool in neurodegenerative diseases such as Parkinson's or Alzheimer's disease. From an ethical point of view, distinguishing between the preservation and an alteration of personal identity seems to be central to determining the scope for further application of brain tissue transplantation therapy. The purpose of this article is to review "standard" arguments which are used on the one hand by proponents to prove preservation of personal identity and by opponents on (...) the other hand to prove that brain tissue transplantation results in an altered personal identity. Proponents and opponents are shown to use the same arguments, albeit with different presuppositions. These presuppositions concern the meaning of the term "identity", either numerical or qualitative, the definition of brain identity, either structurally or functionally, and the relationship between mental states, psychological functions and neurophysiological properties as criteria for personal identity. Furthermore the respective neurophysiological, clinical and philosophical evidence for the different presuppositions are discussed. It is concluded that evaluation of personal identity in brain tissue transplantation should not only rely on the "standard" arguments but, additionally, neurophysiological, clinical and philosophical implications should be discussed. (shrink)

In his article, a unified brain-based determination of death is described by James Bernat (2024) as a permanent cessation of systemic circulation causing a permanent cessation of brain circulation...

We have long used mechanical devices to compensate for physical disability. Soon, however, it may be possible to augment mental capacity—to add memory or upgrade processing power. We should ponder the enormous moral implications of the machine‐assisted mind now, before it is accomplished.

This article is an attempt to clarify a confusion in the brain death literature between logical sufficiency/necessity and natural sufficiency/necessity. We focus on arguments that draw conclusions regarding empirical matters of fact from conceptual or ontological definitions. Specifically, we critically analyze arguments by Tom Tomlinson and Michael B. Green and Daniel Wikler. which, respectively, confuse logical and natural sufficiency and logical and natural necessity. Our own conclusion is that it is especially important in discussing the brain death issue to observe (...) the distinction between logical and natural sufficiency/necessity in a strict fashion. (shrink)

Recently, G. ASSER has obtained two interesting characterizations of the class of unary primitive recursive string-functions over a fixed alphabet as Robinson algebras. Both characterizations use a somewhat artificial string-function, namely the string-function lexicographically associated with the number-theoretical excess-over-a-square function. Our aim is to offer two new and natural Robinson algebras which are equivalent to ASSER’S algebras.

Many accounts of the historical development of neurological criteria for determination of death insufficiently distinguish between two strands of interpretation advanced by advocates of a "whole-brain" criterion. One strand focuses on the brain as the organ of integration. Another provides a far more complex and nuanced account, both of death and of a policy on the determination of death. Current criticisms of the whole-brain criterion are effective in refuting the first interpretation, but not the second, which is advanced in the (...) 2008 President's Council report on the determination of death. In this essay, I seek to further develop this second strand of interpretation. I argue that policy on determination of death aligns moral, biological, and ontological death concepts. Morally, death marks the stage when respect is no longer owed. Biologically, death concerns integrated functioning of an organism as a whole. But the biological concepts are underdetermined. The moral concerns lead to selection of strong individuality concepts rather than weak ones. They also push criteria to the "far side" of the dying process. There is a countervailing consideration associated with optimizing the number of available organs, and this pushes to the "near side" of death. Policy is governed by a conviction that it is possible to align these moral and biological death concepts, but this conviction simply lays out an agenda. There is also a prescription—integral to the dead donor rule—that lexically prioritizes the deontic concerns and that seeks to balance the countervailing tendencies by using science-based refinements to make the line between life and death more precise. After showing how these concerns have been effectively aligned in the current policy, I present a modified variant of a "division" scenario and show how an "inverse decapitation problem" leads to a conclusive refutation of the nonbrain account of death. (shrink)

The present and future rapid increase in the hospital population of geriatric patients is discussed with particular reference to the problem of advanced brain degeneration. The consequences of various clinical management options are outlined and it is suggested that extreme attempts either to preserve or terminate life are medically, morally and socially unacceptable. The preservation of life in senile patients has important economic consequences. In achieving a decision on the medical management of patients with advanced brain decay it is suggested (...) that substantial help would be derived from: knowledge of the previously declared wishes of individual patients; improvements in geriatric assessments; broader consultation with relatives, and greater use of inter-disciplinary discussion in the preparation of criteria for terminating medical efforts to maintain survival. (shrink)

Meditation has been for long time avoided as a scientific theme because of its complexity and its religious connotations. Fortunately, in the last years, it has increasingly been studied within different neuroscientific experimental protocols. Attention and concentration are surely among the most important topics in these experiments. Notwithstanding this, inhibition of emotions and discursive thoughts are equally important to understand what is at stake during those types of mental processes. I philosophically and technically analyse and compare results from neuroimaging studies, (...) produced by leading authorities on the theme, dealing with two types of meditation: "one-pointed concentration" and "compassion meditation". Analysing "one-pointed concentration", I show the differences between novice and expert meditation practitioners in terms of brain activity and connectivity, considering the relationship among increased attention and concentration and decreased activity in areas related to discursive thought and emotion. Analysing "compassion meditation", I show the importance of the limbic circuitry in emotion sharing. I follow the same strategy of comparing novice and expert meditation practitioners. The conclusion establishes a common structure to those different ways of dealing with emotion during meditation. (shrink)

The empirical investigations over the past fifteen years of evolutionary biologists and cognitive scientists have demonstrated the accessibility and power of the human brain. Whatever moral concepts used to acknowledge the normative appraisals of human conduct are now explained through neurological hardwiring. This essay outlines some of the main views of proponents, but especially Marc Hauser, and I argue that it does not render the end of morals. It does provide an opportunity to view the facts of how the brain (...) functions but this essay finds a large domain of valuing unable to be justified by these new scientific challenges. (shrink)

CHAPTER Heidegger and the Quantum Brain In any case the orientation to "I" and " consciousness" and re-presentation ...

This paper argues that if a person's beliefs are idealized as a set of sentences (theoretical, observational, and mixed) then the device of Ramsey sentences provides a treatment, of the mind-brain problem, that has at least four noteworthy characteristics. First, sentences asserting correlations between one's own brain state and one's own "private" experiences are, on such treatment, reconstrued as neither causal, coreferential, nor as meaning postulates, but as clauses in an overall hypothesis (Ramsey sentence) whose only nonlogical constants have "private" (...) meanings. Second, sentences asserting psycho-physical correlations in general, or in other individuals, remain theoretical and susceptible to scientific reduction, though not prejudged to be so. Third, communication between persons having mutually exclusive, "private," observational vocabularies can be made intelligible. Fourth, it becomes possible in principle (though not necessary) that the world could ultimately be given a total description in a scientific language, $L_{\varnothing}$ , without mental primitives. However, such a language would be susceptible to interpretation by a given individual using a metalanguage whose primitives (not among those of $L_{\varnothing}$ ) were privately observational to that individual. His procedure in accomplishing such an interpretation would be to construct a Tarskian truth definition in a metalanguage $ML_{\varnothing}$ and then to incorporate it, by Ramsifying its descriptive terms, in his own overall Ramsey sentence. The physical language, $L_{\varnothing}$ , while not containing a person's primitives, would, of course, be able to define their physical correlates, thus providing a certain sort of mutual mirroring, and a certain sort of relativity. (shrink)

The approach of Revonsuo is criticised as being based on a misplaced emphasis on coupled oscillatory dynamics, as well as on too limited an approach to recent advances in brain imaging. This results in the nature of attention as a basic component in consciousness being ignored, and prevents any attempt to attack the crucial problem for consciousness of inner experience: of ‘what it is like to be’.

The concept of brain birth has assumed a position of some significance in discussions on the status of the human embryo and on the point in embryonic development prior to which experimental procedures may be undertaken on human embryos. This paper reviews previous discussions of this concept, which have placed brain birth at various points between 12 days' and 20 weeks' gestation and which have emphasised the symmetry of brain birth and brain death. Major developmental features of brain development are (...) outlined, including the gradualness with which new features generally appear, and also the electroencephalogram (EEG) characteristics of premature infants. From this it is concluded that, if the concept of brain birth is a valid one, it should be placed at 24-28 weeks' gestation. More importantly, it is concluded that the differences between brain development and brain death throw doubt on the concept itself. (shrink)

The method of positron emission tomography illustrates the circular logic popular in subtractive neuroimaging and linear reductive cognitive psychology. Both require that strictly feed-forward, modular, cognitive components exist, before the fact, to justify the inference of particular components from images after the fact. Also, both require a "true" componential theory of cognition and laboratory tasks, before the fact, to guarantee reliable choices for subtractive contrasts. None of these possibilities are likely. Consequently, linear reductive analysis has failed to yield general, reliable, (...) componential accounts. (shrink)

In the case of magnetic resonance imaging (MRI) imaging, image processing is crucial. In the medical industry, MRI images are commonly used to analyze and diagnose tumor growth in the body. A number of successful brain tumor identification and classification procedures have been developed by various experts. Existing approaches face a number of obstacles, including detection time, accuracy, and tumor size. Early detection of brain tumors improves options for treatment and patient survival rates. Manually segmenting brain tumors from a significant (...) number of MRI data for brain tumor diagnosis is a tough and time-consuming task. Automatic image segmentation of brain tumors is required. The objective of this study is to evaluate the degree of accuracy and simplify the medical picture segmentation procedure used to identify the type of brain tumor from MRI results. Additionally, this work suggests a novel method for identifying brain malignancies utilizing the Bagging Ensemble with K-Nearest Neighbor (BKNN) in order to raise the KNN’s accuracy and quality rate. For image segmentation, a U-Net architecture is utilized first, followed by a bagging-based k-NN prediction algorithm for classification. The goal of employing U-Net is to improve the accuracy and uniformity of parameter distribution in the layers. Each decision tree is fitted on a little different training dataset during classification, and the bagged decision trees are effective since each tree has minor differences and generates slightly different skilled predictions. The overall classification accuracy was up to 97.7 percent, confirming the efficiency of the suggested strategy for distinguishing normal and pathological tissues from brain MR images; this is greater than the methods that are already in use. (shrink)

Pope John Paul II called for an intense dialogue between science and theology, “a common interactive relationship,” in which each discipline is “open to the discoveries and insights of the other” while retaining its own integrity. This essay seeks to be responsive to that call and is an initial exploration of relationships between contemporary neuroscience and Catholic theological ethics. It examines neuroscientific data on the bicameral brain and theological ethical data on marital ethics, including divorce and remarriage, and asks what (...) insight the former might provide into both the latter and the different ethical methods that respond to marital ethics. The analysis is undertaken in the hope of illuminating a pathway that opens the insights of one way of doing theological ethics to the insights of another way, thereby eliminating the unnecessary, unhelpful, and sometimes un‐Christian polarizations that presently separate them. (shrink)

This book results from a group meeting held at the Institute for Scientific Exchange in Torino, Italy. The central aim was for scientists to think together in new ways with those in the humanities inspired by quantum theory and especially quantum brain theory. These fields of inquiry have suffered conceptual estrangement but now are ripe for rapprochement, if academic parochialism is put aside. A prevalent theme of the book is a moving away from individual elements and individual actors acting upon (...) each other, toward a coordinate hermeneutic dynamics that manifests as a coherent totality. Among the topics covered are image in photography and in neuroscience; language; time; brain and mathematics; quantum brain dynamics and quantum communication.". (shrink)

I’m writing to underscore one point, which should be obvious, but which all too often has been neglected in the literature on medical futility. The futility of an action or an intervention is always relative to some goal. Consider the classical example of futility: carrying water in a sieve. If your goal is to transport a quantity of water without spilling some or all of it, then it is futile to do so by placing it in a sieve. But we (...) can readily imagine children carrying water in the backyard in a sieve, enjoying the water spilling out on the grass and trickling down their legs. It’s not futile to serve that goal of having fun. The salience of this point can be tested by examining its relevance to... (shrink)

Grafts of embryonic neural tissue into the brains of adult patients are currently being used to treat Parkinson's disease and are under serious consideration as therapy for a variety of other degenerative and traumatic disorders. This target article evaluates the use of transplants to promote recovery from brain injury and highlights the kinds of questions and problems that must be addressed before this form of therapy is routinely applied. It has been argued that neural transplantation can promote functional recovery through (...) the replacement of damaged nerve cells, the reestablishment of specific nerve pathways lost as a result of injury, the release of specific neurotransmitters, or the production of factors that promote neuronal growth. The latter two mechanisms, which need not rely on anatomical connections to the host brain, are open to examination for nonsurgical, less intrusive therapeutic use. Certain subjective judgments used to select patients who will receive grafts and in assessment of the outcome of graft therapy make it difficult to evaluate the procedure. In addition, little long-term assessment of transplant efficacy and effect has been done in nonhuman primates. Carefully controlled human studies, with multiple testing paradigms, are also needed to establish the efficacy of transplant therapy. (shrink)

The assessment of decision-making capacity in patients with brain injuries presents a range of clinical and legal challenges. Existing guidance on the conduct of such assessments is often generic; guidance specific to patients with brain injury is sparse and coarse-grained. We report on an interview-based study of decision-making capacity in patients suffering from acquired brain injury and organic personality disorder. We identify challenges associated with the assessment of DMC in this patient population, review three bodies of relevant research from cognitive (...) neuropsychology and neurophysiology, and draw on phenomenological analysis to identify three distinct abilities that play a role in decision-making, but which can be compromised in patients with organic personality disorder. We address the challenge of translating clinical findings into legally attestable results. (shrink)

Quantum degrees of freedom greatly enrich nonlinear systems, which can support nonlocal control and superposition of states. Basing my discussion on Yasue’s quantum brain dynamics, I suggest that the Cartesian subject is a cybernetic process rather than a substance: I am nonlocal control and my meanings are cybernetic variables. Meanings as nonlocal attunements are not mechanically determined, thus is it concluded we have freedom to mean.

CHAPTER A Phenomenological Introduction to the Cognitive Neuroscience of Consciousness Peter G. Grossenbacher National Institute of Mental Health What is ...